Saxagliptin Dione Impurity HCl CAS 1350800-77-9 (free base)
| CAS No. | 1350800-77-9 (free base) |
| Molecular Formula | C18H24N2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Saxagliptin Dione Impurity HCl (CAS 1350800-77-9 (free base), C18H24N2O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Saxagliptin Dione Impurity HCl (C18H24N2O3HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Saxagliptin Dione Impurity HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H24N2O3 HCl |
| Molecular Weight | 352.86 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Saxagliptin Standards
- Saxagliptin Impurity N1 (CAS 102502-64-7)
- Saxagliptin Hydrochloride Dihydrate (CAS 1073057-20-1)
- Saxagliptin Impurity N52 (CAS 1194836-75-3)
- Saxagliptin Cyclic Imidine Impurity (CAS 1194836-77-5)
- (±)-Saxagliptin-13C3 (acetyl-13C2,cyclopropyl-3-13C) (CAS 1246812-44-1)
- Saxagliptin-15N,D2 Hydrochloride (CAS 1309934-06-2)
- Saxagliptin Impurity 60 Mesylate (CAS 1312338-82-1)
- Saxagliptin Impurity 6 (CAS 1334321-39-9)
Recommended Standards
- Fudosteine Impurity 86 (CAS CATO-C4X-144786)
- Methylprednisolone EP Impurity H (CAS 18462-27-6)
- Ilaprazole Impurity 58 (CAS 1508282-90-3)
- 1-(3,4-Difluorobenzenesulfonyl)piperidine-4-carboxylic acid (CAS 716361-66-9)
- 3-((1h-Benzo[d]imidazol-2-yl)thio)butan-2-one (CAS 22889-04-9)
- (E)-4-Hydroxy Toremifene (~5% Z-isomer) (CAS 177748-22-0)
- Nicotinic Acid EP Impurity I (CAS 940-06-7)
- 2-Methoxy-N-((2-methoxypyridin-3-yl)methyl)acetamide (CAS 1252442-76-4)
- 6-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)thiophen-2-yl]-18,19-dimethoxy-4,5,9,13-tetraazapentacyclo[11.8.0.0^{3,11}.0^{4,8}.0^{16,21}]henicosa-3(11),5,7,9,16(21),17,19-heptaen-12-one (CAS 685107-20-4)
- Tirzepatide Impurity 15 (CAS CATO-C4X-324015)
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